Precedex Premix Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Dexmedetomidine HCl (in 0.9% w/v NaCl)

Indications/Uses

Sedation of initially intubated & mechanically ventilated patients during treatment in an intensive care setting. Sedation/anxiolysis of non-intubated patients prior to &/or during surgical & other procedures.

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Dosage/Direction for Use

Adult ICU sedation 1 mcg/kg loading infusion over 10 min. Maintenance of ICU sedation 0.2-0.7 mcg/kg/hr. Adjust rate of maintenance infusion to achieve the desired level of sedation. Initiation of procedural sedation 1 mcg/kg loading infusion over 10 min. 0.5 mcg/kg loading infusion over 10 min may be given for less invasive procedures eg, ophth surgery. Maintenance of procedural sedation Initially 0.6 mcg/kg/hr & titrate w/ doses 0.2-1 mcg/kg/hr. Adjust rate of maintenance infusion to achieve the target level of sedation. Awake fiberoptic intubation in adult patient Maintenance: 0.7 mcg/kg/hr until the endotracheal tube is secured.

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Overdosage

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Special Precautions

Advanced heart block &/or severe ventricular dysfunction. Hypotension &/or bradycardia in patients w/ hypovolemia, DM or chronic HTN. Transient HTN primarily during the loading dose. Arousability & alert when stimulated has been observed in some patients. Supportive therapy is indicated if tachycardia &/or HTN occurs after discontinuation in ICU sedation. Tolerance & tachyphylaxis w/ use beyond 24 hr. Clonidine-like w/drawal syndrome upon abrupt discontinuation. Hepatic impairment. Pregnancy (category C) & lactation. Childn. Elderly ≥65 yr.

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Use In Pregnancy & Lactation

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Adverse Reactions

Hypotension, bradycardia & sinus arrest; dry mouth. Nausea, fever, vomiting, hypoxia, tachycardia & anemia.

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Drug Interactions

Enhanced effects w/ anesth, sedatives, hypnotics & opioids.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Precedex Premix detailed prescribing information

Storage

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Description

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Action

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MIMS Class

Hypnotics & Sedatives

ATC Classification

N05CM18 - dexmedetomidine ; Belongs to the class of other hypnotics and sedatives.

Regulatory Classification

Presentation/Packing

Form

Precedex Premix soln for IV infusion 4 mcg/mL

Packing/Price

100 mL x 10 × 1's;50 mL x 20 × 1's

Precedex Premix

dexmedetomidine

Manufacturer:

Hospira

Distributor:

Pfizer