HIGHLIGHT
SmofKabiven/SmofKabiven Peripheral

SmofKabiven/SmofKabiven Peripheral

Manufacturer:

Fresenius Kabi

Distributor:

Zuellig
/
The Glory Medicina
Concise Prescribing Info
Contents
SmofKabiven Per 1000 mL Alanine 7.1 g, arginine 6.1 g, glycine 5.6 g, histidine 1.5 g, isoleucine 2.5 g, leucine 3.8 g, lysine acetate 3.4 g, methionine 2.2 g, phenylalanine 2.6 g, proline 5.7 g, serine 3.3 g, taurine 0.5 g, threonine 2.2 g, tryptophan 1 g, tyrosine 0.2 g, valine 3.1 g, Ca chloride dihydrate 0.28 g, Na glycerophosphate (as hydrate) 2.1 g, Mg sulphate (as heptahydrate) 0.61 g, KCl 2.3 g, Na acetate trihydrate 1.7 g, Zn sulphate (as heptahydrate) 0.0066 g, glucose (as monohydrate) 127 g, soya bean oil (refined) 11.4 g, medium-chain triglycerides 11.4 g, olive oil (refined) 9.5 g, fish oil (rich in omega-3-acids) 5.7 g. SmofKabiven Peripheral Per 1000 mL Glucose (as monohydrate) 71 g, alanine 4.4 g, arginine 3.8 g, glycine 3.5 g, histidine 0.93 g, isoleucine 1.6 g, leucine 2.3 g, lysine acetate 2.1 g, methionine 1.3 g, phenylalanine 1.6 g, proline 3.5 g, serine 2.1 g, taurine 0.32 g, threonine 1.4 g, tryptophan 0.63 g, tyrosine 0.12 g, valine 2 g, Ca chloride dihydrate 0.18 g, Na glycerophosphate (as hydrate) 1.3 g, Mg sulphate (as heptahydrate) 0.38 g, KCl 1.4 g, Na acetate trihydrate 1.1 g, Zn sulphate (as heptahydrate) 0.004 g, soya bean oil (refined) 8.5 g, medium-chain triglycerides 8.5 g, olive oil (refined) 7 g, fish oil (rich in omega-3-acids) 4.2 g
Indications/Uses
Parenteral nutrition for adults & childn ≥2 yr when oral or enteral nutrition is impossible, insufficient or contraindicated.
Dosage/Direction for Use
IV infusion SmofKabiven Adult & adolescents (12-16/18 yr) 13-31 mL/kg/day. Max: 35 mL/kg/day. Childn 2-11 yr Dose up to 35 mL/kg/day should be regularly adjusted to the requirements of the paed patient that varies more than in adult patients. SmofKabiven Peripheral Adult & adolescents (12-16/18 yr) 20-40 mL/kg/day. Max: 40 mL/kg/day. Childn 2-11 yr Dose up to 40 mL/kg/day should be regularly adjusted to the requirements of the paed patient that varies more than in adult patients.
Contraindications
Hypersensitivity to fish, egg, soya or peanut protein. Severe hyperlipidemia, liver insufficiency & blood coagulation disorders; congenital errors of amino acid metabolism; severe renal insufficiency w/o access to hemofiltration or dialysis; acute shock, uncontrolled hyperglycemia; pathologically elevated serum electrolyte levels; acute pulmonary oedema, hyperhydration, decompensated cardiac insufficiency; hemophagocytotic syndrome; unstable conditions eg, severe post-traumatic conditions, uncompensated DM, acute MI, stroke, embolism, metabolic acidosis, severe sepsis, hypotonic dehydration & hyperosmolar coma. Infants & childn <2 yr.
Special Precautions
Discontinue use in the presence of anaphylactic shock. Impaired lipid metabolism in renal & hepatic impairment, DM, pancreatitis, hypothyroidism, sepsis. Correct electrolyte & fluid balance disturbances prior to infusion. Predisposition to electrolyte retention. Monitor serum triglycerides, glucose, electrolytes, osmolarity, fluid balance, acid-base status, liver enzyme tests, blood cell count & coagulation. May interfere w/ laboratory measurements (eg, bilirubin, lactose dehydrogenase, oxygen saturation, hemoglobin). Phosphate & K intake should be controlled in patients w/ renal insufficiency. Lactic acidosis, insufficient cellular oxygen supply, increased serum osmolarity; malnourished patients. Increased urinary excretion of the trace elements particularly copper & Zn in IV infusion of amino acids. Hyperglycemia. Do not give w/ blood in the same infusion set. Pregnancy & lactation. Newborn or infant <2 yr.
Adverse Reactions
Slight increase in body temp. SmofKabiven Peripheral Thrombophlebitis.
Drug Interactions
Increased plasma lipolysis & transient decrease in triglycerides clearance w/ heparin.
MIMS Class
Parenteral Nutritional Products
ATC Classification
B05BA10 - combinations ; Belongs to the class of solutions for parenteral nutrition used in I.V. solutions.
B05BA01 - amino acids ; Belongs to the class of solutions for parenteral nutrition used in I.V. solutions.
Presentation/Packing
Form
SmofKabiven emulsion for infusion
Packing/Price
1477 mL x 1's;1970 mL x 1's;493 mL x 1's;986 mL x 1's
Form
SmofKabiven Peripheral emulsion for infusion
Packing/Price
1206 mL x 1's;1448 mL x 1's;1904 mL x 1's
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